Alzheimer's Disease by Philippe Derreumaux (ed.) PDF

By Philippe Derreumaux (ed.)

ISBN-10: 1848167547

ISBN-13: 9781848167544

Alzheimer's disorder is the commonest type of senile dementia, affecting greater than 24 million humans around the world. it really is characterized pathologically by means of abnormally excessive degrees of neurofibrillary tangles as a result of the buildup of tau protein in useless and demise neurons, and by way of increased numbers of senile plaques within the cortex and hippocampus of the mind. the main element of senile plaques is a small protein of 39-43 amino acids known as amyloid- (A ). to date, no therapy has been proven to sluggish the development of sporadic and familial Alzheimer's affliction.

a wide physique of proof issues, even if, to the early A -formed oligomers because the fundamental poisonous species in Alzheimer's sickness. a robust technique for constructing pharmaceutical remedies opposed to Alzheimer's is to clarify the pathways of oligomer formation and ascertain the constructions of the poisonous aggregates.

This e-book presents a wide ranging view throughout contemporary in vitro and in vivo experiences in addition to state of the art desktop simulations, designed to extend the readers' knowing of A oligomerisation and fibril formation. while, the booklet delves into the pathogenesis of familial and sporadic Alzheimer's illness on the atomic point of aspect.

Written by way of top authors of their respective fields, this booklet may be beneficial to all scientists engaged on Alzheimer's affliction.

Readership: common public, PhD scholars, postdocs, in addition to all scientists operating within the following fields: Alzheimer's disorder, amyloids, neuroscience, oligomers, protofibrils, fibrils, toxicity, constructions, dynamics, kinetics, thermodynamics, all-atom and coarse grained simulations, biophysics, reminiscence, studying, transgenic mouse types, steel ions, membrane, nanoparticles, computational chemistry, drug layout and bioinformatics.

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Additional resources for Alzheimer's Disease

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2007). Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct, J. Biol. , 282, 10311–10324. Neumcke, B. and Lauger, P. (1969). Nonlinear electrical effects in lipid bilayer membranes. II. Integration of the generalized Nernst-Planck equations, Biophys. , 9, 1160–1170. A. M. (2006). Lysosomal system pathways: genes to neurodegeneration in Alzheimer’s disease, J. , 9, 277–289. November 26, 2012 24 10:0 9in x 6in Alzheimer’s Disease: Insights Into Low Molecular … b1377-chA1 R.

Regulation of NMDA receptor trafficking by amyloid-beta, Nat. , 8, 1051–1058. , Glabe, C. E. (2006). Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure, J. Gen. , 128, 637–647. J. T. (2005). Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy, J. , 25, 7278–7287. Stefani, M. M. (2003). Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution, J.

2010). , 277, 1347. G. and LeBlanc, A. (2003). p75 neurotrophin receptor protects primary cultures of human neurons November 26, 2012 28 10:0 9in x 6in Alzheimer’s Disease: Insights Into Low Molecular … b1377-chA1 R. Kayed and C. A. Lasagna-Reeves against extracellular amyloid beta peptide cytotoxicity, J. , 23, 7385–7394. B. W. (2004). Amyloid beta prevents activation of calcium/calmodulin-dependent protein kinase II and AMPA receptor phosphorylation during hippocampal long-term potentiation, J.

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Alzheimer's Disease by Philippe Derreumaux (ed.)

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