By Angélique Van’t Wout, Richard A. Koup, William A. Paxton (auth.), Hanneke Schuitemaker, Frank Miedema (eds.)
Infection with the human immunodeficiency virus is characterised via the destruction of the host immune process as additionally mirrored by way of a innovative lack of CD4-positive T-cells. This eventually leads to the host's incapability to house opportunistic infections and the immune surveillance of tumors, a scientific prestige referred to as the received Immunodeficiency Syndrome (AIDS).
The publication AIDS Pathogenesis presents the reader with a whole assessment of the scientific process HIV-1 an infection. It describes the scientific facets of fundamental an infection, the several medical results of HIV-1 an infection, and methods for anti-viral remedy. furthermore, extra primary points of HIV-1 an infection are reviewed. those comprise the biology of the virus and the unconventional insights in AIDS pathogenesis. not just is the importance of an HIV-specific mobile and humoral immune reaction mentioned, but in addition the prospective incapability of the grownup human host to accommodate T-cell destruction. eventually, the e-book discusses the at the moment used laboratory markers that let for tracking of the medical process infection.
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H. : The risk of transfusiontransmitted viral infections: the retrovirus epidemiology donor study, New Engl. J. Med. 334 (1996), 1685-1690. Primary HIV Infection 89. 90. 91. 92. 93. 94. 95. 96. 97. 98. 99. 100. 101. 102. 103. 104. 105. 106. 107. lOS. 109. 110. Ill. 112. 113. , et al: Acute HIV-1 infection: Clinical and biological study of 12 patients, J. Acq. Immune Def Syndr. Human Retrovir. 3 (1990), 260-265. , et al: Cytokine network and acute HIV-1 infection, AIDS 7 (1993), 625-631. R. : Bidirectional interaction between human immunodeficiency virus type 1 and cytomegalovirus, J.
70 (1996), 3098-107. , Wolinsky, S. : Evidence for coinfection by multiple strains of human immunodeficiency virus type I infection subtype B in an acute seroconvertor, J Viral. 69 (I 995), 1324-1327. O. : Postnatal transmission of AIDSassociated retrovirus from mother to infant, Lancet i (1985), 896-898. CHAPTER3 BIOLOGICAL VARIABILITY OF HIV-1 JAN ALBERT 1 and MAARTEN KOOT2 Department of Clinical Virology, Swedish Institute for Infectious Disease Control, Karolinska Institute, S-I05 2I Stockholm, Sweden, and 2Department of Clinical Viro-Immunology of the CLB and Laboratory for Experimental and Clinical Immunology, Academic Medical Centre, University ofAmsterdam, Amsterdam, The Netherlands 1 1.
A rapid, simple assay can now determine the presence of plasma HIV resistant to most reverse transcriptase inhibitors . If antiretroviral therapy is to be used in those with primary HIV infection, it would be advantageous to determine the drug susceptibility prior to commencing therapy. Similar assays assessing protease inhibitor resistance are in development. 3. 1. T-cell Subsets Primary HIV infection is characterised by rapid changes in peripheral T-lymphocyte subsets [29,69,82,112]. During the first 1 to 2 weeks there characteristically is lymphopenia affecting both CD4+ and CD8+ subsets.
AIDS Pathogenesis by Angélique Van’t Wout, Richard A. Koup, William A. Paxton (auth.), Hanneke Schuitemaker, Frank Miedema (eds.)