By P. D. Aplan, M. Stanulla (auth.), Prof. Dr. T. Büchner, Prof. Dr. med. W. Hiddemann, Prof. Dr. B. Wörmann, Prof. Dr. G. Schellong, Prof. Dr. J. Ritter, Prof. Dr. U. Creutzig (eds.)
Since 1987 Acute Leukemias (AL) has frequently said at the state-of-the-art within the speedily becoming, profitable and fascinating box of biology and administration of those ailments. during this quantity huge multicenter medical trials back shape the forged foundation for the research of leukemic mobile biology, the detection of biologic subgroups, their differential reaction to substitute remedy recommendations and the extra improvement of remedy. specifically, this quantity addresses mechanisms of chromosomal translocations and transcription elements, risk-adapted therapy recommendations, differentiation remedy, secondary AL, detailed points in older sufferers, and adoptive immunotherapy. in addition to the antileukemic ways, supportive remedy with new antimicrobial ingredients and development elements is up-to-date. As a discussion board of globally actions within the box of AL this quantity comprises either exhaustive overviews on significant scientific matters and initial information and hypotheses now not formerly published.
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Extra info for Acute Leukemias VIII: Prognostic Factors and Treatment Strategies
FONATSCH 5 , B. SCHLEGELBERGER6 , D. HAASE3 , C. -D. LUDWIG7 , W. HIDDEMANN 1 and S. K. BOHLANDER4 ABSTRACI The t(10,1l)(p13;qI4) is a recurring translocation that has been observed in acute lymphoblastic as well as acute myeloid leukemia. A previous study revealed a MLLIAFIO fusion in all cases of AML with t(10;l1) and various breakpoints on chromosome 11 ranging from q13 to q23. In contrast, we recently cloned CALM (Clathrin Assembly Lymphoid Myeloid leukemia gene), another fusion partner of AFIO located at 11qI4, in the monocytic cell line U937.
In Cooper DKC, Novitsky D eds. The transplantation and replacement of thor acic organs. The presents status of biological and mechanica l replacement of the heart and lungs. Dordrecht, Kluwer Academic Publishers, 1990; p 183. Penn I. The effect of immunosuppression on preexisting cancer s. Transplantation 55 (4): 742-747, 1993. Nalesnik MA, Makowka L,Starzl TE. The diagnosis and treatment of posttransplant Iymphoprolifer ative disorders. Curr Probl Surg,25: 367-472, 1988. Armitage JM, Kormos RL, Stuart RS, Fricker FJ, Griffith BP, Nalesnik M, Hardsty RL.
7 and 9, data not shown). Discussion The translocation t(IO;1l)(pI3;qI4) is a recurring chromosomal abnormality that has been observed in acute lymphoblastic as well as acute myeloid leukemia (Berger et al. 1989; Berger et al. 1995; Heim et al. 1989; Sait et al. 1987). On the molecular level, two types of t(IO;11)(pl3;ql3-q21) have been characterized so far, both of them involve the putative transcription factor APlO on lOpl3. One type results in a MLLIAPlO fusion, the other one causes a CALM/APlO fusion (Chaplin et al.
Acute Leukemias VIII: Prognostic Factors and Treatment Strategies by P. D. Aplan, M. Stanulla (auth.), Prof. Dr. T. Büchner, Prof. Dr. med. W. Hiddemann, Prof. Dr. B. Wörmann, Prof. Dr. G. Schellong, Prof. Dr. J. Ritter, Prof. Dr. U. Creutzig (eds.)